|
Esophageal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray.
|
17068819 |
2007 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.
|
28319090 |
2017 |
|
Lung Diseases, Interstitial
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
|
23583980 |
2013 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, genetic alterations within the candidate cancer susceptibility gene AKAP13 would be expected to provoke a constitutive Rho signalling, thereby facilitating the development of cancer.
|
16234258 |
2006 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In a first phase, the LBC ONC characterized the phenotype and molecular aberration profiles of LSC in various malignancies.
|
30006759 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We used LBC, based on SurePathTM (BD Diagnostics) technology, to screen 96 peritoneal fluid samples from patients with known malignancies and from 10 control patients with cirrhosis.
|
30024911 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, genetic alterations within the candidate cancer susceptibility gene AKAP13 would be expected to provoke a constitutive Rho signalling, thereby facilitating the development of cancer.
|
16234258 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In 2008 the Ludwig Boltzmann Cluster Oncology (LBC ONC) was established on the basis of two previous Ludwig Boltzmann Institutes working in the field of hematology and cancer research.
|
30006759 |
2018 |
|
Chronic granulomatous disease
|
0.020 |
AlteredExpression
|
group |
BEFREE |
This observation suggests that patients with CGD may also have a defect in lymphocyte function. p47 protein and mRNA levels increase during retinoic acid-induced neutrophil differentiation of HL60 cells.
|
2398896 |
1990 |
|
Chronic granulomatous disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
A male CGD patient with pg91(phox) deficiency exhibited a trend toward prolongation of this calcium response, whereas two other CGD patients (one with p47 and one with 67(phox) deficiencies) had normal calcium transients.
|
15527168 |
2004 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Stratifying breast tumors on ERα Serine 305 phosphorylation status resulted in the identification of a gene network centered upon AKAP13.
|
26272591 |
2015 |
|
Mammary Neoplasms
|
0.020 |
GeneticVariation
|
group |
LHGDN |
Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer.
|
16234258 |
2006 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, the concept of preleukemic (premalignant) neoplastic stem cells (pre-L-NSC) was coined by the LBC ONC and was tested in myelodysplastic syndromes and myeloproliferative neoplasms.
|
30006759 |
2018 |
|
MYELODYSPLASTIC SYNDROME
|
0.020 |
Biomarker
|
group |
BEFREE |
Only 30% of patients with MDS achieved complete remission (CR) after two cycles of AML-directed therapy, compared with 88% of patients with AML-LBC (P=0.0001); MDS patients tended to experience prolonged severe cytopenias with chemotherapy.
|
9009082 |
1997 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In the colorectal cancer, AKAP13 and ROCK1/2 were highly expressed in adenocarcinoma compared to the control tissue and low-grade dysplasia.
|
28434818 |
2017 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ASE reduced oxidative damage markers (TBARS, carbonyl levels and 8-isoprostane) in D and DH associated with a decrease in Nox 4 and p47 subunit expression and increase in antioxidant enzyme activity in both groups (SOD, catalase and GPx).
|
28105508 |
2018 |
|
HTLV-I Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The mechanism of p47 degradation is primarily dependent on activation of lysosomal-autophagy and the autophagy is activated in most of the HTLV-infected and ATLL cells, suggesting that the p47 degradation may be a first key molecular event during HTLV-1 infection to T-cells as a connector of two important signaling pathways, NF-κB and autophagy.
|
30837480 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we identified the XIAP enzymatic substrate p47 as a positive regulator of the <i>I. scapularis</i> IMD network.
|
30559180 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We have now established the PsiNCF1 to NCF1 ratio for a significant number of IBD patients (n = 488) and control subjects (n = 181) and show that there is no statistically significant difference between the frequency of the 1:1 ratio in CD (11.2%) or UC (12.2%) patients and controls (13.4%).
|
15626894 |
2004 |
|
Myeloproliferative disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, the concept of preleukemic (premalignant) neoplastic stem cells (pre-L-NSC) was coined by the LBC ONC and was tested in myelodysplastic syndromes and myeloproliferative neoplasms.
|
30006759 |
2018 |
|
Uterine Fibroids
|
0.010 |
Biomarker
|
group |
BEFREE |
Because AKAP13 augmented nuclear receptor signaling in other tissues, we sought to determine whether AKAP13 might influence PR signaling in fibroids.
|
30239831 |
2019 |